BioV®
Bioactive Matrix
BioV® Bioactive Matrix is a novel bone graft substitute specifically designed to optimize surgical handling, graft stability, and osteoproductivity. It is a synergistic combination of Bioactive Glass and Demineralized Bone Matrix.
Bioactive Glass is an osteoconductive and osteopromotive material that guides new bone formation. Characteristics are based on in vivo and animal data.
- Forms a strong interfacial bond between the graft and adjacent bony tissue within minutes1
- Triggers the mechanisms that cause differentiation and proliferation of osteoblasts2
- Boosts activity of critical growth factors needed for bone formation3
- Accelerates the process of osteogenesis4
- Demonstrate via in vitro studies that ionic release (Ca++) and local pH changes inherent to Bioactive Glass create an unfavorable environment for the growth of certain microbes5
Demineralized allograft bone is an osteoconductive scaffold with osteoinductive potential to facilitate new bone formation.6
- DBM lots evaluated for osteoinductive potential using an in vivo athymic rat model
- Processed to achieve a sterility assurance level (SAL) of 10-6
- Surface roughness of DBM particles allow for migration and proliferation of osteogenic cells7
- Demineralization process exposes natural morphogenic proteins in the bone matrix, making them available for osteogenesis8
A patented process integrates the osteoinductive and osteoconductive elements of the product.9 This allows for rapid reconstitution and easy preparation. The product is moldable and extrudable, can be packed into osseous defects, and resists migration during irrigation - allowing the active components to stay in place.
1 Oonishi H, Kushitani S, Yasukawa E, Iwaki H, Hench LL, Wilson J, Tsuji E, Sugihara T (1997) Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop Relat Res 334:316–325.
2 Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141.
3 Mulliken JB, Glowacki J, Kaban LB, Folkman J, Murray JE (1981) Use of demineralized allogeneic bone implants for the correction of maxillocraniofacial deformities. Ann Surg 194(3):366–372.
4 Mulliken JB, Kaban LB, Glowacki J (1984) Induced osteogenesis—the biological principle and clinical applications. J Surg Res 37(6):487–496.
5 Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141.
6 BervenS, TayBK, KleinstueckFS, Bradford DS(2001)Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation. Eur Spine J 10(Suppl 2):S169–S177. doi:10.1007/s005860100270.
7 Kirk T. J, (2012) Osteoconductivity and osteoinductivity of Bio V DBM. Cell Tissue Bank DOI 10.1007/s10561-012-9297-1.
8 Mulliken JB, Kaban LB, Glowacki J (1984) Induced osteogenesis—the biological principle and clinical applications. J Surg Res 37(6):487–496.
9 Kirk T. J, (2012) Osteoconductivity and osteoinductivity of Bio V DBM. Cell Tissue Bank DOI 10.1007/s10561-012-9297-1.
Documents and Specifications
